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Keep an eye on Intently (one)pentobarbital will lower the extent or effect of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on into a decrease in fentanyl plasma concentrations, deficiency of efficacy or, probably, progress o